{"id":7246,"date":"2022-12-12T18:21:00","date_gmt":"2022-12-12T18:21:00","guid":{"rendered":"https:\/\/bostonsp.com\/?p=7246"},"modified":"2023-08-24T19:37:13","modified_gmt":"2023-08-24T19:37:13","slug":"early-albumin-infusion-is-associated-with-greater-survival-to-discharge-among-patients-with-sepsis-septic-shock-who-develop-severe-acute-kidney-injury-among-patients-with-sepsis-septic-shock-who-devel","status":"publish","type":"post","link":"https:\/\/bostonsp.com\/index.php\/2022\/12\/12\/early-albumin-infusion-is-associated-with-greater-survival-to-discharge-among-patients-with-sepsis-septic-shock-who-develop-severe-acute-kidney-injury-among-patients-with-sepsis-septic-shock-who-devel\/","title":{"rendered":"Early Albumin Infusion Is Associated With Greater Survival to Discharge Among Patients With Sepsis\/Septic Shock Who Develop Severe Acute Kidney Injury Among Patients With Sepsis\/Septic Shock Who Develop Severe Acute Kidney Injury"},"content":{"rendered":"

Raghunathan, K., Kempker, J. A., Davis, E. A., Sindhwani, N. S., Telang, S., Lodaya, K., & Martin, G. S. (2022). Early Albumin Infusion Is Associated With Greater Survival to Discharge Among Patients With Sepsis\/Septic Shock Who Develop Severe Acute Kidney Injury Among Patients With Sepsis\/Septic Shock Who Develop Severe Acute Kidney Injury.\u00a0Critical care explorations<\/i>,\u00a04<\/i>(12), e0793. https:\/\/doi.org\/10.1097\/CCE.0000000000000793<\/a> Erratum in: Crit Care Explor. 2023 Jan 18;5(1):e0852.<\/p>\n

View article<\/strong><\/a><\/p>\n\n\n

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Abstract<\/h4>\n

Importance:<\/strong> Adults hospitalized with sepsis\/septic shock commonly develop acute kidney injury (AKI) which imposes a significant burden on the healthcare system. The administration of early human albumin in this patient population may yield more efficient healthcare resource utilization.<\/p>\n

Objectives:<\/strong> To examine the association between early use of albumin and time to discharge in adults who develop severe AKI while hospitalized with sepsis\/septic shock.<\/p>\n

Design:<\/strong> Retrospective cohort study using de-identified electronic health records from a national database (Cerner Health Facts; Cerner Corp., Kansas City, MO).<\/p>\n

Setting and participants:<\/strong> Patients (n = 2,829) hospitalized between January 2013 and April 2018 with a diagnosis of sepsis\/septic shock (identified using International Classification of Diseases, 9th Revision and 10th Revision codes) who developed severe AKI (stage 3 according to Kidney Disease Improving Global Outcomes criteria) during hospitalization (n = 2,845 unique encounters).<\/p>\n

Main outcomes and measures:<\/strong> Patients were grouped according to timing of albumin exposure: within less than or equal to 24 hours of admission (“early albumin”) or unexposed\/exposed late (“nonearly albumin”). A cause-specific hazard model, censoring for death\/discharge to hospice, was used to examine the association between “early albumin” and the rate of hospital discharge with clinical stability.<\/p>\n

Results:<\/strong> Albumin was administered early in 8.6% of cases. Cases with early albumin administration had a median time to discharge of 13.2 days compared with 17.0 in the nonearly group (Log-rank p < 0.0001). An adjusted analysis showed that the rate of hospital discharge with clinical stability increased by 83% in the early albumin group compared with the nonearly group (hazard ratio, 1.832; 95% CI, 1.564-2.146; p < 0.001 nonearly group.<\/p>\n

Conclusions and relevance:<\/strong> The use of albumin within 24 hours of hospital admission was associated with a shorter time to discharge and a higher rate of discharge with clinical stability, suggesting an improvement in healthcare resource utilization among patients with sepsis\/septic shock who developed stage 3 AKI during hospitalization.<\/p>","protected":false},"excerpt":{"rendered":"

Raghunathan, K., Kempker, J. A., Davis, E. A., Sindhwani, N. S., Telang, S., Lodaya, K., & Martin, G. S. (2022). Early Albumin Infusion Is Associated With Greater Survival to Discharge Among Patients With Sepsis\/Septic Shock Who Develop Severe Acute Kidney Injury Among Patients With Sepsis\/Septic Shock Who Develop Severe Acute Kidney Injury.\u00a0Critical care explorations,\u00a04(12), e0793. […]<\/p>\n","protected":false},"author":7,"featured_media":7250,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_wpcom_ai_launchpad_first_post":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[9],"tags":[157,162,163,108,164,158,159,136,99,25,56,160],"class_list":["post-7246","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications","tag-acute-kidney-injury","tag-albumin-infusion","tag-cerner-health-facts","tag-electronic-health-records","tag-generalized-linear-models","tag-human-serum-albumin","tag-length-of-stay","tag-logistic-regression","tag-real-world-evidence","tag-retrospective-study","tag-sepsis","tag-septic-shock"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t