{"id":7232,"date":"2023-01-16T14:01:00","date_gmt":"2023-01-16T14:01:00","guid":{"rendered":"https:\/\/bostonsp.com\/?p=7232"},"modified":"2023-08-24T19:42:45","modified_gmt":"2023-08-24T19:42:45","slug":"association-of-acei-arb-and-statin-prescribing-patterns-with-mortality-after-transcatheter-aortic-valve-replacement-tavr-findings-from-real-world-claims-data","status":"publish","type":"post","link":"https:\/\/bostonsp.com\/index.php\/2023\/01\/16\/association-of-acei-arb-and-statin-prescribing-patterns-with-mortality-after-transcatheter-aortic-valve-replacement-tavr-findings-from-real-world-claims-data\/","title":{"rendered":"Association of ACEI\/ARB and statin prescribing patterns with mortality after Transcatheter Aortic Valve Replacement (TAVR): Findings from real-world claims data"},"content":{"rendered":"

Cubeddu, R. J., Murphy, S. M. E., Asher, C. R., Garcia, S. A., Granada, J. F., Don, C. W., Patel, S., Albaghdadi, M. S., Cavalcante, J. L., Coylewright, M., Hahn, R. T., Genereux, P., Yadav, P. K., Thourani, V. H., & Leon, M. B. (2023). Association of ACEI\/ARB and statin prescribing patterns with mortality after Transcatheter Aortic Valve Replacement (TAVR): Findings from real-world claims data. American Heart<\/em> Journal,<\/em> 258, 27\u201337. https:\/\/doi.org\/10.1016\/j.ahj.2022.12.012<\/a><\/p>\n

View article<\/strong><\/a><\/p>\n\n\n

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Abstract<\/h4>\n

Background: <\/strong>Transcatheter aortic valve replacement (TAVR) has become the standard of care for most patients with severe aortic stenosis (AS), but the impact of medical therapy prescribing patterns on post-TAVR patients has not been thoroughly investigated.<\/p>\n

Methods:<\/strong> We analyzed Optum claims data from 9,012 adults who received TAVR for AS (January 2014-December 2018). Pharmacy claims data were used to identify patients who filled ACEI\/ARB and\/or statin prescriptions during the study’s 90-day landmark period post-TAVR. Kaplan-Meier and adjusted Cox Proportional Hazards models were used to evaluate the association of prescribing patterns with mortality during the 3-year follow-up period. Subgroup analyses were performed to examine the impact of 11 potential confounders on the observed associations.<\/p>\n

Results:<\/strong> A significantly lower adjusted 3-year mortality was observed for patients with post-TAVR prescription for ACEI\/ARBs (hazard ratio [HR] = 0.82, 95% confidence interval [CI] 0.74-0.91, P = .0003) and statins (HR = 0.85, 95% CI 0.77-0.94, P = .0018) compared to patients who did not fill prescriptions for these medications post-TAVR. Subgroup analyses revealed that the survival benefit associated with ACEI\/ARB prescription was not affected by any of the potential confounding variables, except preoperative ACEI\/ARB prescription was associated with significantly lower risk of mortality vs postoperative prescription only. No other subgroup variables had significant interactions associated with survival benefits, including preoperative use of statins.<\/p>\n

Conclusions:<\/strong> In this large-scale, real-world analysis of patients undergoing TAVR, the prescription of ACEI\/ARB and statins was associated with a significantly lower risk of mortality at 3-years, especially in those where the medications were initiated preoperatively.<\/p>\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Cubeddu, R. J., Murphy, S. M. E., Asher, C. R., Garcia, S. A., Granada, J. F., Don, C. W., Patel, S., Albaghdadi, M. S., Cavalcante, J. L., Coylewright, M., Hahn, R. T., Genereux, P., Yadav, P. K., Thourani, V. H., & Leon, M. B. (2023). Association of ACEI\/ARB and statin prescribing patterns with mortality after […]<\/p>\n","protected":false},"author":7,"featured_media":7235,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[9],"tags":[140,144,92,122,143,99,139,133,141,142,138],"class_list":["post-7232","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications","tag-acei-arb","tag-adjusted-cox-proportional-hazards-models","tag-aortic-stenosis","tag-kaplan-meier","tag-optum-database","tag-real-world-evidence","tag-renin-angiotensin-system-inhibitor","tag-retrospective","tag-statin","tag-statin-prescription-mortality","tag-transcatheter-aortic-valve-replacement"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t