Report Overview

In 2014, US healthcare spending exceeded $3.0 trillion with nearly 1/3 spent on hospitalizations. Informed by real-world data from an Electronic Health Record (EHR) database of clinical and administrative records spanning 273 million encounters for 60 million patients in 600+ hospitals across the US, Boston Strategic Partners (BSP) Real World data report, Hospital Treated Sepsis, estimates 30% of all hospital discharges involve treatment of infectious organisms. Sepsis is responsible for an estimated 12% of all hospital stays. At an average cost of $15,500 per occurrence, we estimate that hospitalizations for severe infections account for $212 billion in annual spending or 7% of total healthcare expenditure. In this report, we conduct an in-depth analysis of sepsis patient characteristics, medication management, costs, and laboratory testing.

Gram-positive bacteria are the likely causative agents of most sepsis infections. Physicians treat the vast majority of these infections with vancomycin, piperacillin-tazobactam, levofloxacin, and ceftriaxone. From 2010-2015, drug-resistant organisms caused an astonishing 40% of bacterial sepsis infections. After confirmatory diagnosis, over half of sepsis patients undergo a change in antibiotic therapy.

BSP provides quantitative, objective data using real-world patient encounters and reflects real physician decisions and encounter characteristics (e.g. patient response to therapy and outcomes) in key areas, such as antibiotic resistant pathogens and antimicrobial stewardship.

Table of Contents 

  1. Outline
  2. Executive Summary
  3. Incidence and Impact of Disease
    • Incidence
    • Length of Stay
    • Total Cost
  4. Patient Demographics
    • Age
    • Insurance type
    • Gender
    • Region
    • Mortality
    • Comorbid Conditions
  5. Patient Segmentation by Diagnostic Testing
    • Causative Etiologic Agent
  6. Length of Stay and Cost by Patient Segment
    • Age at Admission
    • APACHE II Score
    • First Care Setting
  7. Patient Flow through the Hospital
    • Admission Site
    • Lab Testing
    • Lab TAT
    • Results
    • Etiology
    • Empiric Therapy
    • Change in treatment
  8. Drug Share for Key Therapeutics
    • Most Common
    • LOS
    • APACHE Score
    • Treatment Duration
    • Product Dashboards
      • Market Share
      • Demographics
      • Hospitalization
  9. Outcomes of Treatment
    • Antibiotic Usage
    • Mortality
    • Cost per Patient
  10. Drug Resistant Sepsis
    • Current Trends
    • Costs
    • Comorbidity
    • LOS
    • Mortality
  11. Database Overview
  12. Methodology

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